Chronic Fatigue & ME
Restore your energy.
Important: R1SE services are complementary wellness support, not medical treatment. Always consult your healthcare provider before starting any new programme, especially if you are under active medical care.
ME/CFS is one of the most misunderstood conditions - and the worst advice anyone can give is to push through it. At R1SE Sheffield, we offer pacing-compatible recovery therapies that support your body without depleting your limited energy reserves.
The 2021 NICE guideline (NG206) represents a watershed moment for ME/CFS care: graded exercise therapy (GET) is explicitly no longer recommended, and post-exertional malaise (PEM) is now recognised as the cardinal diagnostic feature. The underlying biology points to measurable mitochondrial dysfunction, impaired oxygen utilisation, autonomic nervous system disturbance (particularly orthostatic intolerance and POTS), and chronic low-grade neuroinflammation. This means meaningful recovery support must act on cellular energy machinery passively - without forcing a depleted system to generate more demand. At R1SE we focus on modalities where you lie still and the therapy does the work: HBOT for oxygen delivery and neuroinflammation, Red Light for mitochondrial ATP, and pneumatic compression for circulation and vagal tone. Movement, if it ever enters your plan, comes last and only on your terms.
Your Multi-Therapy Plan
How R1SE Can Help
The Science
Evidence-based insights supporting our approach.
Muscle biopsies from ME/CFS patients show measurable mitochondrial dysfunction: reduced ATP production, impaired respiratory chain activity, and elevated oxidative stress (Myhill et al., 2009, International Journal of Clinical & Experimental Medicine) - providing a biological rationale for mitochondrial-targeting therapies.
The 2021 NICE guideline (NG206) explicitly removed graded exercise therapy (GET) as a recommended treatment for ME/CFS following the PACE trial reanalysis. Pacing and energy-envelope management are now the standard of care.
A 2013 pilot study at the University of the Health Sciences, Warsaw found 15 sessions of HBOT produced significant improvements in fatigue severity scale scores and quality of life in ME/CFS patients, with effects sustained at follow-up.
Photobiomodulation at 810nm increases mitochondrial membrane potential and ATP synthesis in human cells by up to 150% (Hamblin, 2018, AIMS Biophysics) - a direct intervention on the core biological deficit in ME/CFS.
Up to 50% of ME/CFS patients also meet criteria for POTS (postural orthostatic tachycardia syndrome). Lower-limb compression improves venous return and reduces orthostatic symptoms - recommended by Dysautonomia International as first-line non-pharmacological support.
A 2020 study in the Journal of Translational Medicine identified persistent immune activation and chronic low-grade neuroinflammation as hallmarks of ME/CFS - mechanisms HBOT has been shown to modulate through HIF-1α signalling and microglial regulation.
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Whether you want to book a session, explore our recovery therapies, or speak to someone about a personalised plan - we are here for you.