Hyperbaric Oxygen Therapy
The most researched recovery therapy in the world.
Important: R1SE services are complementary wellness support, not medical treatment. Always consult your healthcare provider before starting any new programme, especially if you are under active medical care.
Hyperbaric Oxygen Therapy (HBOT) involves breathing pure oxygen in a pressurised chamber at 1.5 ATA - increasing the oxygen dissolved in your blood plasma by 10-15x normal levels. This hyper-oxygenation triggers a cascade of healing responses: angiogenesis (new blood vessel formation), stem cell mobilisation, neuroplasticity, telomere lengthening, senescent cell clearance, and the modulation of over 8,000 genes involved in inflammation, growth, and repair. R1SE Sheffield offers clinical-grade HBOT as part of our multi-therapy approach - the only facility in Sheffield combining HBOT with Red Light Therapy, contrast therapy, and expert-led movement.
HBOT is not new - it has been used medically since the 1930s and is approved by the NHS for decompression sickness, carbon monoxide poisoning, and non-healing wounds. What is new is the explosion of research showing HBOT's benefits for healthy ageing (telomere lengthening, senescent cell clearance), brain health (concussion, cognitive function, neuroplasticity), chronic conditions (long COVID, fibromyalgia, autoimmune conditions), and athletic performance (tissue repair, recovery acceleration). At R1SE, HBOT is not a standalone treatment - it is the cornerstone of a multi-therapy protocol where pressurised oxygen amplifies the benefits of everything else you do.
Your Multi-Therapy Plan
How R1SE Can Help
The Science
Evidence-based insights supporting our approach.
HBOT at 1.5 ATA dissolves oxygen into blood plasma at 10-15x normal atmospheric levels, reaching hypoxic (oxygen-starved) tissues that red blood cells cannot access due to inflammation, poor circulation, or structural damage.
A landmark 2020 study found HBOT increased telomere length by 20% and reduced senescent cells by 37% in healthy adults aged 64+ - the first intervention ever shown to reverse two hallmarks of biological ageing simultaneously (Hadanny et al., Aging).
HBOT modulates over 8,000 genes involved in inflammation, growth factor production, stem cell mobilisation, and immune regulation. It is not simply 'more oxygen' - it is a comprehensive cellular reprogramming stimulus (Godman et al., 2010, Genomic Medicine).
A randomised controlled trial found HBOT significantly improved cognitive function, quality of life, and brain perfusion (measured by SPECT imaging) in persistent post-concussion patients - demonstrating measurable brain healing (Boussi-Gross et al., 2013, PLOS ONE).
HBOT promotes angiogenesis - the formation of new blood vessels - through VEGF (vascular endothelial growth factor) stimulation. This is particularly relevant for tendons, cartilage, and peripheral nerves, which have naturally poor blood supply.
HBOT stimulates stem cell release from bone marrow by up to 800% after a series of 20 sessions - mobilising the body's own repair cells to damaged tissue (Thom et al., 2006, American Journal of Physiology).
HBOT reduces neuroinflammation through NF-kB pathway modulation and has shown benefit in clinical trials for long COVID, fibromyalgia, PTSD, TBI, and post-stroke recovery - conditions characterised by persistent neuroinflammation.
The NHS approves HBOT for decompression sickness, carbon monoxide poisoning, and non-healing wounds. The growing evidence base for broader applications (longevity, brain health, chronic conditions) has driven the expansion of HBOT into wellness facilities like R1SE Sheffield.
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